7H-Furo[3',2':4,5]furo[2,3-c]xanthen-7-one,3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR,12cS)- (10048-13-2)

 Sterigmatocystin ,its cas register number is 10048-13-2. It also can be called 7H-Furo(3',2':4,5)furo(2,3-c)xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy-  ; 7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR,12cS)- and (3aR,12cS)-8-Hydroxy-6-méthoxy-3a,12c-dihydro-7H-furo[3',2':4,5]furo[2,3-c]xanthén-7-one . It is a poison of the type dermatoxin, from the fungi genus Aspergillus, and is a toxic metabolite structurally closely related to the aflatoxins (compare general fact sheet number 2), and consists of a xanthone nucleus attached to a bifuran structure. The occurrence of sterigmatocystin in raw materials and foods has not been reported often. No country has legislation for Sterigmatocystin (CAS NO.10048-13-2). Natural occurrence appears to be infrequent although only a limited number of surveys have been carried out. Its relatively high levels have been formed in bread, cured ham and salami after inoculation with A. versicolor. And, methods for extraction of sterigmatocystin have been commonly based on a mixture of acetonitrile and 4% aqueous potassium chloride.

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 245.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.