1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)- (105219-56-5)

Identification
Name:	1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-
Synonyms:	Morpholine,4-[3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]-(9CI); 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, morpholine deriv.;Apafant; WEB 2086BS; Web 2086
CAS:	105219-56-5
Molecular Formula:	C22H22 Cl N5 O2 S
Molecular Weight:	455.96
InChI:	InChI=1/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
Molecular Structure:
Properties
Density:	1.48g/cm³
Refractive index:	1.733
Specification:	? Apafant (CAS No.105219-56-5), its synonyms are 4-(3-(4-(o-Chlorophenyl)-9-methyl-6H-thieno(3,2-f)-s- ; Triazolo(4,3-a)(1,4)diazepin-2-yl)propionyl)morpholine ; 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone .
Biological Activity:	Potent, selective platelet-activating factor (PAF) receptor antagonist (K i = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.
Usage:	Platelet activating factor (PAF) antagonist.
Safety Data