| Identification |
| Name: | 1(2H)-Isoquinolinone,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]- |
| Synonyms: | 1H-1,4-Diazepine,1-[(1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro- (9CI); HA 1100;Hydroxyfasudil |
| CAS: | 105628-72-6 |
| Molecular Formula: | C14H17 N3 O3 S |
| Molecular Weight: | 307.36808 |
| InChI: | InChI=1/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H |
| Molecular Structure: |
![(C14H17N3O3S) 1H-1,4-Diazepine,1-[(1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro- (9CI); HA 1100;Hydroxyfas...](https://img1.guidechem.com/chem/e/dict/26/105628-72-6.jpg) |
| Properties |
| Flash Point: | 325°C |
| Boiling Point: | 613.7°Cat760mmHg |
| Density: | 1.329g/cm3 |
| Biological Activity: | Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo . |
| Flash Point: | 325°C |
| Safety Data |
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