| Identification |
| Name: | 1H-1,4-Diazepine,1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-, hydrochloride (1:1) |
| Synonyms: | 1H-1,4-Diazepine,1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-, monohydrochloride (9CI);1-(5-Chloronaphthyl-1-sulfonyl)homopiperazine hydrochloride;ML 9; |
| CAS: | 105637-50-1 |
| Molecular Formula: | C15H18Cl2N2O2S |
| Molecular Weight: | 361.29 |
| InChI: | InChI=1/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H |
| Molecular Structure: |
![(C15H18Cl2N2O2S) 1H-1,4-Diazepine,1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-, monohydrochloride (9CI);1-(5-Chlor...](https://img1.guidechem.com/chem/e/dict/46/105637-50-1.jpg) |
| Properties |
| Melting Point: | 196-200 |
| Flash Point: | 261.5°C |
| Boiling Point: | 508.8°Cat760mmHg |
| Density: | g/cm3 |
| Solubility: | ethanol: 10 mg/mL |
| Appearance: | crystalline solid |
| Biological Activity: | Selective inhibitor of myosin light chain kinase (MLCK). K i values are 32, 4, and 54 μ M for PKA, MLCK, and PKC respectively. Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca 2+ entry (SOCE). |
| Flash Point: | 261.5°C |
| Storage Temperature: | 2-8°C |
| Color: | white |
| Usage: | Inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. Also found to be a new type of vascular relaxant |
| Safety Data |
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