Imidazo[1,2-a]pyridine-2,3-dione,hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)- (109944-15-2)

Identification
Name:	Imidazo[1,2-a]pyridine-2,3-dione,hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)-
Synonyms:	Imidazo[1,2-a]pyridine-2,3-dione,hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, [5R-(5a,6b,7a,8a,8aa)]-; (+)-Kifunensine; FR 900494; Kifunensine
CAS:	109944-15-2
Molecular Formula:	C8H12 N2 O6
Molecular Weight:	232.19
InChI:	InChI=1/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
Molecular Structure:
Properties
Flash Point:	°C
Boiling Point:	°Cat760mmHg
Density:	1.85g/cm³
Refractive index:	1.706
Biological Activity:	Inhibitor of class I α -mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α -1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with K i values of 130 and 23 nM respectively.
Flash Point:	°C
Storage Temperature:	−20°C
Usage:	Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing e
Safety Data