| Identification |
| Name: | L-Leucinamide,N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]- |
| Synonyms: | L-Leucinamide,N-acetyl-L-leucyl-N-(1-formylpentyl)-, (S)-; ALLN; ALLnL; CI-1 (peptide); CalpI; Calpain inhibitor I; MG 101; N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal |
| CAS: | 110044-82-1 |
| Molecular Formula: | C20H37 N3 O4 |
| Molecular Weight: | 383.53 |
| InChI: | InChI=1/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1 |
| Molecular Structure: |
 |
| Properties |
| Flash Point: | 192.9°C |
| Boiling Point: | 632.2°Cat760mmHg |
| Density: | 1.02g/cm3 |
| Refractive index: | 1.473 |
| Biological Activity: | Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression. |
| Flash Point: | 192.9°C |
| Storage Temperature: | −20°C |
| Color: | white |
| Safety Data |
| |
 |
