Identification |
Name: | Raltitrexed |
Synonyms: | D1694;Tomudex (TN);L-Glutamic acid,N-[[5-[[(1,4-dihydro-2- methyl-4-oxo-6-quinazolinyl)methyl]methylamino]- 2-thienyl]carbonyl]-;ZD1694;Raltitrexed (JAN/USAN);D 1694;(2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid;L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)-;Tomudex;ICI-D1694;ICI D1694;N-(5-(N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid;(S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid;ZD 1694;D-1694; |
CAS: | 112887-68-0 |
Molecular Formula: | C21H22N4O6S |
Molecular Weight: | 458.49 |
InChI: | InChI=1/C21H22N4O6S/c1-11-22-14-4-3-12(9-13(14)19(28)23-11)10-25(2)17-7-6-16(32-17)20(29)24-15(21(30)31)5-8-18(26)27/h3-4,6-7,9,15H,5,8,10H2,1-2H3,(H,24,29)(H,26,27)(H,30,31)(H,22,23,28)/t15-/m0/s1 |
Molecular Structure: |
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Properties |
Melting Point: | 176-1800C |
Density: | 1.49 g/cm3 |
Refractive index: | 1.638 |
Appearance: | yellow crystalline powder |
Specification: |
? Raltitrexed , with CAS number of 112887-68-0, can be called L-glutamic acid, N-[[5-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]- ; L-glutamic acid, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]- ; N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic acid ; N-[(5-{Methyl[(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}-2-thienyl)carbonyl]-L-glutamic acid , it is a yellow crystalline powder. It is a?Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives.
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Usage: | Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic |
Safety Data |
Hazard Symbols |
Xi: Irritant
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