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Estra-1,3,5(10)-triene-3,17-diol(17b)-, 3,17-dipropanoate (113-38-2)

Identification
Name:Estra-1,3,5(10)-triene-3,17-diol(17b)-, 3,17-dipropanoate
Synonyms:Estra-1,3,5(10)-triene-3,17-diol(17b)-, dipropanoate (9CI);Estradiol, dipropionate (6CI,7CI,8CI); 1,3,5(10)-Estratriene-3,17b-diol dipropionate; 17b-Estradiol 3,17-dipropionate; 17b-Estradiol dipropionate; 3,17b-Dipropionoxyestra-1,3,5(10)-triene;3,17b-Estradiol dipropionate;Agofollin; Dimenformon dipropionate; Diovocyclin; Diovocylin; Diprostron; EndofollicolinaD. P.; Estradiol 3,17-dipropionate; Estradiol propionate; Estroici; Estronex;Follicyclin P; Nacyclyl; Oestradiol 3,17-dipropionate; Ovahormon Depot;Ovocyclin P; Ovocyclin dipropionate; Progynon DP; b-Estradiol dipropionate
CAS:113-38-2
EINECS: 204-026-5
Molecular Formula: C24H32 O4
Molecular Weight: 384.56
InChI: InChI=1/C21H28O3/c1-3-20(23)24-19-9-8-18-17-6-4-13-12-14(22)5-7-15(13)16(17)10-11-21(18,19)2/h5,7,12,16-19,22H,3-4,6,8-11H2,1-2H3/t16?,17?,18?,19-,21-/m0/s1
Molecular Structure: (C24H32O4) Estra-1,3,5(10)-triene-3,17-diol(17b)-, dipropanoate (9CI);Estradiol, dipropionate (6CI,7CI,8CI); 1,...
Properties
Flash Point: 238.5°C
Boiling Point: 487.8°Cat760mmHg
Density:1.14g/cm3
Refractive index:1.577
Specification:

 Estradiol dipropionate , with cas register number of 113-38-2, is called EDP for short. Its IUPAC name is [(8R,9S,13S,14S,17S)-13-methyl-3-propanoyloxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] propanoate and the systematic name is (17beta)-estra-1,3,5(10)-triene-3,17-diyl dipropanoate with the SMILES of O=C(Oc1cc3c(cc1)[C@H]2CC[C@@]4([C@@H](OC(=O)CC)CC[C@H]4[C@@H]2CC3)C)CC. Moreover, its superlist Name is called Oestradiol dipropionate . This compound is a kind of Steroids.

  The physical properties of Estradiol dipropionate include: (1)H bond acceptors: 4; (2)H bond donors: 0; (3)Freely Rotating Bonds: 6; (4)Index of Refraction: 1.554; (5)Molar Refractivity: 107.59 cm3; (6)Molar Volume: 335.7 cm3 ; (7)Surface Tension: 45.5 dyne/cm; (8)Enthalpy of Vaporization: 75.38 kJ/mol; (9)Vapour Pressure: 1.15E-09 mmHg at 25°C.

  Estradiol dipropionate is a poison by intravenous and parenteral routes. When heated to decomposition it emits acrid smoke and irritating fumes. It has the limited evidence of a carcinogenic effect and the danger of serious damage to health by prolonged exposure. When use it, do not breathe dust and avoid contact with skin and eyes.

   Estradiol dipropionate is a drug for the treatment of menopause. It has the experimental reproductive effects. The toxicity has done like:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 175, 1990.

Report:

IARC Cancer Review: Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 , 1979,p. 279.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Flash Point: 238.5°C
Safety Data
Hazard Symbols Xn: Harmful
 

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