| Identification |
| Name: | 6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo- |
| Synonyms: | 2,3-Dioxo-7-nitro-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX;FG 9065; |
| CAS: | 115066-14-3 |
| Molecular Formula: | C9H4N4O4 |
| Molecular Weight: | 232.15246 |
| InChI: | InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15) |
| Molecular Structure: |
 |
| Properties |
| Density: | 1.71 g/cm3 |
| Refractive index: | 1.803 |
| Water Solubility: | in water: 10 mg/mL |
| Solubility: | in water: 10 mg/mL |
| Appearance: | Pale Yellow Solid |
| Biological Activity: | Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex. |
| Color: | orange to red |
| Usage: | A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively |
| Safety Data |
| Hazard Symbols |
Xi: Irritant
|
| |
 |
