| Identification | |
| Name: | 1,2,3-Propanetricarboxylicacid,1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl]ester, (2R,2'R)- |
| Synonyms: | 1,2,3-Propanetricarboxylicacid,1,1'-[1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl]ester, [2S-[1[1R*(S*),2S*(S*),2(S*)],2R*,4S*,9S*,11R*,12R*]]-;Macrofusine; |
| CAS: | 116355-83-0 |
| EINECS: | 201-067-0 |
| Molecular Formula: | C34H59NO15 |
| Molecular Weight: | 721.82996 |
| InChI: | InChI=1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48) |
| Molecular Structure: |  |
| Properties | |
| Transport: | 3172 |
| Density: | 1.254 g/cm3 |
| Refractive index: | 1.527 |
| Water Solubility: | soluble in water to at least 20 mg/mL; soluble in polar organic solvents as methanol or acetonitrile (1). FB1 is insoluble in chloroform and hexane. |
| Solubility: | soluble in water to at least 20 mg/mL; soluble in polar organic solvents as methanol or acetonitrile (1). FB1 is insoluble in chloroform and hexane. |
| Appearance: | white hygroscopic powder |
| Specification: |
Macrofusine ,its CAS NO. is 116355-83-0,the synonyms is Fumonisin b1 ; Fumonisin b1, fusarium moniliforme ;Fb1 ; 1,2,3-Propanetricarboxylic acid 1,1'-[1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl] ester . |
| Report: |
IARC Cancer Review: Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 56 ,1993,p. 445.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . |
| Packinggroup: | III |
| Biological Activity: | Mycotoxin produced by Fusarium moniliforme . Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC 50 ~ 75 nM). Also inhibits protein phosphatases; IC 50 values are 80, 300, 400, 500 and 3000 μ M for PP5, PP2C α , PP2A, PP1 γ 2 and PP2B respectively. |
| Storage Temperature: | 2-8°C |
| Color: | Powder |
| Safety Data | |
| Hazard Symbols |
T: Toxic
Xn: Harmful
F: Flammable
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