9H-Carbazole-9-propanoicacid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)- (116649-85-5)

Identification
Name:	9H-Carbazole-9-propanoicacid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)-
Synonyms:	9H-Carbazole-9-propanoicacid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (R)-;BAY-u3405;Baynas;
CAS:	116649-85-5
Molecular Formula:	C₂₁H₂₁FN₂O₄S
Molecular Weight:	416.47
InChI:	InChI=1/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
Molecular Structure:
Properties
Density:	1.43 g/cm³
Stability:	Stable at normal temperatures and pressures.
Refractive index:	1.664
Solubility:	0.5 g/L (25 C)
Appearance:	Crystalline solid.
Specification:	Ramatroban , its CAS NO. is 116649-85-5, the synonyms are (+)-(3R)-3-(p-Fluorobenzenesulfonamido)-1,2,3,4- tetrahydrocarbazole-9-propionic acid ; 3-(4-Fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid ; Bay u-3405 ; Baynas ; UNII-P1ALI72U6C ; 9H-Carbazole-9-propanoic acid, 3-(((4-fluorophenyl)sulfonyl)amino)-1,2,3,4-tetrahydro-, (R)- .
Biological Activity:	Potent dual antagonist of TP/DP 2 (CRTH2) prostanoid receptors (K i values are 4.3, 4.5 and > 10000 nM for hDP 2 , hTP and hDP 1 receptors respectively). Suppresses PGD 2 -induced migration of human eosinophils (IC 50 = 170 nM).
Usage:	A thromboxane receptor antagonist indicated for the treatment of coronary artery disease. It has also been used for the treatment of asthma.
Safety Data