| Identification |
| Name: | Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]- |
| Synonyms: | AG 18;2-(3,4-Dihydroxybenzylidene)malononitrile;Propanedinitrile,[(3,4-dihydroxyphenyl)methylene]- (9CI);(3,4-Dihydroxybenzylidene)malononitrile;RG 50858;TX 825;Tyrphostin 23;AG 18 (pharmaceutical);Tyrphostin AG 18;RG 50810; |
| CAS: | 118409-57-7 |
| Molecular Formula: | C10H6N2O2 |
| Molecular Weight: | 186.16684 |
| InChI: | InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H |
| Molecular Structure: |
![(C10H6N2O2) AG 18;2-(3,4-Dihydroxybenzylidene)malononitrile;Propanedinitrile,[(3,4-dihydroxyphenyl)methylene]- (...](https://img1.guidechem.com/chem/e/dict/186/118409-57-7.jpg) |
| Properties |
| Density: | 1.428 g/cm3 |
| Refractive index: | 1.696 |
| Appearance: | Yellow-tan solid |
| Biological Activity: | Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling. |
| Usage: | A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM) |
| Safety Data |
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