| Identification |
| Name: | 1H-Indole-2-propanoicacid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)- |
| Synonyms: | L663536; MK 886 |
| CAS: | 118414-82-7 |
| Molecular Formula: | C27H34 Cl N O2 S |
| Molecular Weight: | 472.08 |
| InChI: | InChI=1/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31) |
| Molecular Structure: |
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| Properties |
| Flash Point: | 330.8°C |
| Boiling Point: | 623.4°Cat760mmHg |
| Density: | 1.14g/cm3 |
| Refractive index: | 1.58 |
| Biological Activity: | An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo . |
| Flash Point: | 330.8°C |
| Storage Temperature: | 2-8°C |
| Color: | white |
| Usage: | Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes. |
| Safety Data |
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