| Identification |
| Name: | 1H-Carbazole-1-aceticacid, 6,8-difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-,(-)- |
| Synonyms: | L 670596 |
| CAS: | 121083-05-4 |
| Molecular Formula: | C22H21 F2 N O4 S |
| Molecular Weight: | 433.47 |
| InChI: | InChI=1/C22H21F2NO4S/c1-30(28,29)16-7-5-13(6-8-16)12-25-21-14(9-20(26)27)3-2-4-17(21)18-10-15(23)11-19(24)22(18)25/h5-8,10-11,14H,2-4,9,12H2,1H3,(H,26,27) |
| Molecular Structure: |
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| Properties |
| Flash Point: | 373.2°C |
| Boiling Point: | 693.4°Cat760mmHg |
| Density: | 1.43g/cm3 |
| Refractive index: | 1.636 |
| Biological Activity: | Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo . |
| Flash Point: | 373.2°C |
| Safety Data |
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