| Identification |
| Name: | Carbonic acid,(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl4-hydroxyphenyl ester, stereoisomer |
| Synonyms: | Perylene,carbonic acid deriv.; Calphostin C; Cladochrome E; PKF 115-584; UCN 1028C |
| CAS: | 121263-19-2 |
| Molecular Formula: | C44H38 O14 |
| Molecular Weight: | 790.76412 |
| InChI: | InChI=1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45,48-49H,16-17H2,1-6H3 |
| Molecular Structure: |
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| Properties |
| Density: | 1.48 g/cm3 |
| Refractive index: | 1.707 |
| Water Solubility: | Soluble in DMF: 1 mg/mL |
| Solubility: | Soluble in DMF: 1 mg/mL |
| Appearance: | red to brown powder |
| Biological Activity: | Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM). |
| Storage Temperature: | −20°C |
| Color: | red to brown |
| Safety Data |
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