| Identification | |
| Name: | Vinorelbine tartrate |
| Synonyms: | Vinorelbine ditartrate (JAN);Navelbine (TN);Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12R,19alpha)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt);KW 2307;Navelbine;Nor-5-anhydrovinblastine ditartrate;C-Norvincaleukoblastine, 3,4-didehydro-4-deoxy-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2) (salt);Vinorelbine ditartrate;Vinorelbine ditartate;3', 4'-didehydro-4'-deoxy- C '-norvincaleukoblastine;Vinorelbineditartrate;Vinorelbine tartrate, USP; |
| CAS: | 125317-39-7 |
| Molecular Formula: | C45H54N4O8.2(C4H6O6) |
| Molecular Weight: | 1079.10594 |
| InChI: | InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28?,37-,38+,39+,42+,43+,44-,45-;2*1-,2-/m011/s1 |
| Molecular Structure: |  |
| Properties | |
| Transport: | OTH |
| Density: | 1.36g/cm3 |
| Refractive index: | 1.675 |
| Water Solubility: | 10 mg/mL in water |
| Solubility: | 10 mg/mL in water |
| Appearance: | white to off-white crystalline powder |
| Specification: |
?Vinorelbine tartrate , with CAS number of 125317-39-7, can be called Vinorelbine ditartrate ; Nor-5'-anhydrovinblastine ditartrate ; C'-Norvincaleukoblastine, 3',4'-didehydro-4'-deoxy-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2) (salt) ; 3',4'-Didehydro-4'-deoxy-8'-norvincaleukoblastine L-(+)-tartrate (1:2) (salt) . |
| Biological Activity: | Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC 50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC 50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations. |
| Color: | off-white |
| Usage: | An antineoplastic |
| Safety Data | |
| Hazard Symbols |
Xi:Irritant
|
 |
|
