| Identification |
| Name: | 5-Isoquinolinesulfonamide,N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]- |
| Synonyms: | 5-Isoquinolinesulfonamide,N-[2-[[3-(4-bromophenyl)-2-propenyl]amino]ethyl]- (9CI);H 89(pharmaceutical);Protein kinase inhibitor H89; |
| CAS: | 127243-85-0 |
| Molecular Formula: | C20H20BrN3O2S |
| Molecular Weight: | 446.3607 |
| InChI: | InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+ |
| Molecular Structure: |
![(C20H20BrN3O2S) 5-Isoquinolinesulfonamide,N-[2-[[3-(4-bromophenyl)-2-propenyl]amino]ethyl]- (9CI);H 89(pharmaceutica...](https://img1.guidechem.com/chem/e/dict/15/127243-85-0.jpg) |
| Properties |
| Melting Point: | 195-200ºC |
| Flash Point: | 340.7 639.7 ºC at 760 mmHg |
| Boiling Point: | 639.7 639.7 ºC at 760 mmHg at 760 mmHg |
| Density: | 1.436 g/cm3 |
| Appearance: | off-white powder |
| Biological Activity: | Protein kinase A inhibitor that also inhibits several other kinases (IC 50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB α and MAPKAP-K1b). |
| Flash Point: | 340.7 639.7 ºC at 760 mmHg |
| Storage Temperature: | 2-8°C |
| Color: | off-white |
| Usage: | Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of
0.0048 uM |
| Safety Data |
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