2H-Naphth[1,8-cd]isothiazole,2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide (127625-29-0)

Identification
Name:	2H-Naphth[1,8-cd]isothiazole,2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide
Synonyms:	2-[3-[4-(p-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphth[1,8-cd]isothiazole1,1-dioxide; Fananserin; RP 62203
CAS:	127625-29-0
Molecular Formula:	C23H24 F N3 O2 S
Molecular Weight:	425.519
InChI:	InChI=1/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
Molecular Structure:
Properties
Flash Point:	341.5°C
Boiling Point:	641.1°Cat760mmHg
Density:	1.331g/cm³
Refractive index:	1.659
Biological Activity:	5-HT 2A receptor antagonist that also displays high affinity at D 4 receptors (K i values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT 2A , D 4 , H 1 , α 1 , 5-HT 1A and D 2 receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro (IC 50 = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo .
Flash Point:	341.5°C
Safety Data