| Identification |
| Name: | 6H-Oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione,8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-,(1aR,2Z,4E,14R,15aR)- |
| Synonyms: | Monorderne; |
| CAS: | 12772-57-5 |
| Molecular Formula: | C18H17ClO6 |
| Molecular Weight: | 364.77698 |
| InChI: | InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3+ |
| Molecular Structure: |
 |
| Properties |
| Transport: | UN 2811 6.1/PG 3 |
| Density: | 1.364 g/cm3 |
| Refractive index: | 1.583 |
| Water Solubility: | ethanol: 10 mg/mL ,Soluble in DMSO (20 mg/ml-clear colorless solution) |
| Solubility: | ethanol: 10 mg/mL ,Soluble in DMSO (20 mg/ml-clear colorless solution) |
| Appearance: | White/yellow powder |
| Biological Activity: | Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis. |
| Storage Temperature: | −20°C |
| Color: | yellow |
| Safety Data |
| Hazard Symbols |
Xn: Harmful
|
| |
 |
