9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylicacid, 11,12,13,13α-tetrahydro-7-methoxy-9-oxo-, ethyl ester, (13αS)-, (130477-52-0)

Identification
Name:	9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylicacid, 11,12,13,13α-tetrahydro-7-methoxy-9-oxo-, ethyl ester, (13αS)-,
CAS:	130477-52-0
Molecular Formula:	C₁₈H₁₉N₃O₄
Molecular Weight:	341.36
InChI:	InChI=1/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
Molecular Structure:
Properties
Flash Point:	307.2°C
Boiling Point:	584.4°Cat760mmHg
Density:	1.42g/cm³
Refractive index:	1.675
Water Solubility:	DMSO: 6 mg/mL
Solubility:	DMSO: 6 mg/mL
Appearance:	powder
Biological Activity:	Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Flash Point:	307.2°C
Safety Data