1H-Pyrrole-2,5-dione,3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)- (133052-90-1)

Identification
Name:	1H-Pyrrole-2,5-dione,3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-
Synonyms:	2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide;
CAS:	133052-90-1
Molecular Formula:	C₂₅H₂₄N₄O₂
Molecular Weight:	412.48366
InChI:	InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
Molecular Structure:
Properties
Density:	1.3 g/cm³
Water Solubility:	soluble in DMSO: ~1 mg/ml
Solubility:	soluble in DMSO: ~1 mg/ml
Appearance:	orange solid
Biological Activity:	Very potent and selective inhibitor of protein kinase C, selective for the α and β 1 isoforms (IC 50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μ M for α , β 1, δ , ε , and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC 50 values are 0.6, 4.6, and 33 μ M respectively). Potent antagonist at the 5-HT 3 receptor (K i = 29.5 nM). Anti-inflammatory in vivo . Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Storage Temperature:	2-8°C
Safety Data
Hazard Symbols	Xn: Harmful