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L-Alaninamide,(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- (138449-07-7)

Identification
Name:L-Alaninamide,(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-
Synonyms:L-Alaninamide,trans-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;FK 888
CAS:138449-07-7
Molecular Formula: C36H36 N4 O4
Molecular Weight: 0
InChI: InChI=1/C36H36N4O4/c1-38-23-30(29-14-8-9-15-32(29)38)35(43)40-22-28(41)20-33(40)34(42)37-31(36(44)39(2)21-24-10-4-3-5-11-24)19-25-16-17-26-12-6-7-13-27(26)18-25/h3-18,23,28,31,33,41H,19-22H2,1-2H3,(H,37,42)/t28-,31+,33+/m1/s1
Molecular Structure: (C36H36N4O4) L-Alaninamide,trans-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalen...
Properties
Flash Point: 499.2°C
Boiling Point: 901.9°Cat760mmHg
Density:1.26g/cm3
Refractive index:1.658
Biological Activity: Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.
Flash Point: 499.2°C
Safety Data
 

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