| Identification |
| Name: | b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylester, hydrochloride (1:1) |
| Synonyms: | b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylester, hydrochloride (9CI); b-Alanine, N,N-dimethyl-,5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylester, hydrochloride, [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-; 1H-Naphtho[2,1-b]pyran, b-alanine deriv.;6-(3-Dimethylaminopropionyl)forskolin hydrochloride; Adehl; Colforsin dapropatehydrochloride; NKH 477 |
| CAS: | 138605-00-2 |
| EINECS: | 266-410-9 |
| Molecular Formula: | C27H43 N O8 . Cl H |
| Molecular Weight: | 546.09 |
| InChI: | InChI=1/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1 |
| Molecular Structure: |
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| Properties |
| Flash Point: | 176°C |
| Boiling Point: | 571.4°Cat760mmHg |
| Density: | g/cm3 |
| Biological Activity: | Water-soluble analog of forskolin ([3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one ) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC 50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo . Also available as part of the PKA Tocriset™ . |
| Flash Point: | 176°C |
| Safety Data |
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