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Neomycin (1404-04-2)

Identification
Name:Neomycin
Synonyms:Bycomycin;Fradiomycin;Jernadex;Myacyne;Neomas;Neomin;Pimavecort;Vonamycin Powder V;
CAS:1404-04-2
EINECS: 215-773-1
Molecular Formula: C23H46N6O13
Molecular Weight: 614.645
InChI: InChI=1/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
Molecular Structure: (C23H46N6O13) Bycomycin;Fradiomycin;Jernadex;Myacyne;Neomas;Neomin;Pimavecort;Vonamycin Powder V;
Properties
Flash Point: 586.5°C
Boiling Point: 1046.1°C at 760 mmHg
Density:1.61 g/cm3
Solubility:Sol in water, methanol, acidified alcohols; practically insol in common org solvents
Soluble in water up to 250 mg/mL
Specification:

Neomycin as a DNA binder
Pilch and coworkers' study showed that the association constant for neomycin with A-site RNA was found to be in the ~109 range. However over 50 years after its discovery, its DNA binding properties were still unknown. In 2000, Arya and coworkers discovered that neomycin induces enormous thermal stabilization of triplex DNA while having little or almost no effect on the DNA duplex stabilization. They also showed that, neomycin likes anything that adopts A-form type structure, triplex DNA being one of them. Their continuous search for selective ligands for a particular type of nucleic acid gave rise to many new conjugates.

Report:

  Neomycin (CAS NO.1404-04-2) is reported in EPA TSCA Inventory.

Flash Point: 586.5°C
Storage Temperature: 2-8°C
Color: Amorphous
Safety Data
Hazard Symbols Xn: Harmful
 

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