| Identification | |
| Name: | Polymyxin B |
| Synonyms: | polymyxin B 2.5sulfate entahydrate;Polymyxin B (base and/or unspecified salts) |
| CAS: | 1404-26-8 |
| EINECS: | 215-768-4 |
| Molecular Formula: | C43H82N16O12 |
| Molecular Weight: | 1189.34256 |
| InChI: | InChI=1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4) |
| Molecular Structure: |  |
| Properties | |
| Density: | g/cm3 |
| Specification: |
Alters cytoplasmic membrane permeability by binding to a negatively charged site in the lipopolysaccharide layer which has an electrostatic attraction for the positively charged amino groups in the cyclic peptide portion (this site normally is a binding site for calcium);Fatty acid portion dissolves in hydrophobic region of membrane and disrupts membrane integrity;Leakage of cellular molecules, inhibition of cellular respiration;Binds and inactivates endotoxin;Relative absence of selective toxicity: nonspecific for cell membranes of any type, highly toxic. |
| Safety Data | |
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