| Identification |
| Name: | 1H-Imidazole,5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) |
| Synonyms: | 1H-Imidazole,4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, monohydrochloride (9CI);Dex;Dexdomitor;Dexmetomidine;Precedex;4-((S)-alpha,2,3-Trimethylbenzyl)imidazole monohydrochloride;Dexmedetomidine HCL; |
| CAS: | 145108-58-3 |
| Molecular Formula: | C13H16N2.HCl |
| Molecular Weight: | 236.74048 |
| InChI: | InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1 |
| Molecular Structure: |
![(C13H16N2.HCl) 1H-Imidazole,4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, monohydrochloride (9CI);Dex;Dexdomitor;Dexmetomi...](https://img.guidechem.com/casimg/145108-58-3.gif) |
| Properties |
| Melting Point: | 153 - 158ºC |
| Flash Point: | 191.3 ºC |
| Boiling Point: | 381.9 ºC at 760 mmHg |
| Water Solubility: | Soluble to 100 mM in Water and to 100 mM in DMSO |
| Solubility: | Soluble to 100 mM in Water and to 100 mM in DMSO |
| Appearance: | White or almost white crystalline powder |
| Biological Activity: | Active isomer of Medetomide (4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride ), a potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. |
| Flash Point: | 191.3 ºC |
| Safety Data |
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