| Identification |
| Name: | 2-Propenamide,3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano- |
| Synonyms: | AG 825;Tyrphostin AG 825 |
| CAS: | 149092-50-2 |
| Molecular Formula: | C19H15 N3 O3 S2 |
| Molecular Weight: | 397.47 |
| InChI: | InChI=1/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+ |
| Molecular Structure: |
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| Properties |
| Flash Point: | 370.7°C |
| Boiling Point: | 689.3°Cat760mmHg |
| Density: | 1.48g/cm3 |
| Refractive index: | 1.732 |
| Water Solubility: | Soluble to 100 mM in DMSO |
| Solubility: | Soluble to 100 mM in DMSO |
| Appearance: | Yellow solid |
| Biological Activity: | Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells. |
| Flash Point: | 370.7°C |
| Storage Temperature: | −20°C |
| Safety Data |
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