| Identification | |
| Name: | Calcium folinatc |
| Synonyms: | Folinic acid Calcium salt; calcium folinate; Folinic acid calcium salt USP28; Calcium leucovorin; LeucovorinCalcium; CALCIUM FOLINATE(FOLINIC ACID)(RG); Folinic acid; Calcium Levofolinate; Leucovorin Calcium; calcium2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl] aminopentanedioate; L-Calcium Folinate |
| CAS: | 1492-18-8 |
| EINECS: | 216-082-8 |
| Molecular Formula: | C20H21CaN7O7 |
| Molecular Weight: | 511.5 |
| InChI: | InChI=1/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1 |
| Molecular Structure: |  |
| Properties | |
| Transport: | OTH |
| Melting Point: | 240-250 |
| Density: | g/cm3 |
| Stability: | Stable at normal temperatures in tightly closed containers under an inert atmosphere. |
| Solubility: | Sparingly soluble in water |
| Appearance: | yellow crystalline powder |
| Specification: |
? Folinic acid (CAS No.1492-18-8), generally administered as calcium folinate (or leucovorin calcium), is an adjuvant used in cancer chemotherapy involving the drug methotrexate.It is also used in synergistic combination with the chemotherapy agent 5-fluorouracil.It is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.While not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be re-dosed until the methotrexate level is less than 5 x 10-8 M.It is also used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer. In this case, folinic acid is not used for "rescue" purposes ; rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase. |
| Storage Temperature: | Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from light and air. |
| Color: | Crystals from water with 3 mol of water of crystallization. |
| Usage: | An adjuvant used in cancer chemotherapy involving the drug methotrexate. |
| Safety Data | |
| Hazard Symbols |
Xn:Harmful
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