| Identification |
| Name: | 1-Naphthalenesulfonamide,5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)- |
| Synonyms: | BMS 182874 |
| CAS: | 153042-42-3 |
| Molecular Formula: | C17H19 N3 O3 S |
| Molecular Weight: | 345.4161 |
| InChI: | InChI=1/C17H19N3O3S/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4/h5-10,19H,1-4H3 |
| Molecular Structure: |
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| Properties |
| Flash Point: | 271°C |
| Boiling Point: | 524.5°Cat760mmHg |
| Density: | 1.332g/cm3 |
| Refractive index: | 1.646 |
| Biological Activity: | Potent, selective and competitive non-peptide endothelin ET A receptor antagonist (K i = 48 nM). Displays > 1000-fold selectivity over ET B receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo . In vitro inhibits ET-1-induced longitudinal muscle contraction in the mouse colon. |
| Flash Point: | 271°C |
| Safety Data |
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