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1H-Indole-2-carboxylicacid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]- (153436-22-7)

Identification
Name:1H-Indole-2-carboxylicacid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-
Synonyms:1H-Indole-2-carboxylicacid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]- (9CI);1H-Indole-2-carboxylic acid,4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, (E)-; GV 150526; GV150526X; Gavestinel
CAS:153436-22-7
Molecular Formula: C18H12 Cl2 N2 O3
Molecular Weight: 375.21
InChI: InChI=1/C18H12Cl2N2O3.Na/c19-10-8-13(20)16-12(17(18(24)25)22-14(16)9-10)6-7-15(23)21-11-4-2-1-3-5-11;/h1-9,22H,(H,21,23)(H,24,25);/q;+1/p-1/b7-6+;
Molecular Structure: (C18H12Cl2N2O3) 1H-Indole-2-carboxylicacid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]- (9CI);1H-Indole-...
Properties
Flash Point: 377.8°C
Boiling Point: 701.1°Cat760mmHg
Density:1.561g/cm3
Biological Activity: Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .
Flash Point: 377.8°C
Safety Data
Hazard Symbols
 

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