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1,4,8,11-Tetraazacyclotetradecane,1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8) (155148-31-5)

Identification
Name:1,4,8,11-Tetraazacyclotetradecane,1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8)
Synonyms:1,4,8,11-Tetraazacyclotetradecane,1,1'-[1,4-phenylenebis(methylene)]bis-, octahydrochloride (9CI);1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride;
CAS:155148-31-5
Molecular Formula: C28H54N8.8ClH
Molecular Weight: 502.78
InChI: InChI=1/C28H54N8.8ClH.2H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;2*1H2
Molecular Structure: (C28H54N8.8ClH) 1,4,8,11-Tetraazacyclotetradecane,1,1'-[1,4-phenylenebis(methylene)]bis-, octahydrochloride (9CI);1,...
Properties
Density:0.962g/cm3
Biological Activity: Highly selective CXCR4 chemokine receptor antagonist (IC 50 values are 0.02 - 0.13 and > 25 μ M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC 50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo .
Safety Data
 

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