7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)- (157286-86-7)

Identification
Name:	7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-
Synonyms:	CP 154526
CAS:	157286-86-7
Molecular Formula:	C23H32 N4
Molecular Weight:	364.53
Molecular Structure:
Properties
Biological Activity:	Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
Safety Data

Other Product

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)
N-(3-Methyl-2-butenyl)-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-6,7-dihydro-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,5-bromo-N,N-dimethyl-7-b-D-ribofuranosyl-
N-(furan-2-ylmethyl)-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,5-bromo-7-(2,4-dichlorophenyl)-2-methyl-N-2-propenyl-N-(1-propylbutyl)-
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-(1-phenylethyl)-N-(2-pyridinylmethyl)-
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,5-(4-chlorophenyl)-N-ethyl-7-(4-methylphenyl)-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,4-chloro-7-[(5-methoxy-4,6-dimethyl-3-pyridinyl)methyl]-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,4-chloro-7-[(5-methoxy-4,6-dimethyl-1-oxido-3-pyridinyl)methyl]-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,4-bromo-7-[(5-methoxy-4,6-dimethyl-3-pyridinyl)methyl]-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,4-bromo-7-[(5-methoxy-4,6-dimethyl-1-oxido-3-pyridinyl)methyl]-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,7-[(2,6-difluorophenyl)methyl]-N-[4-[(1-methyl-3-piperidinyl)oxy]phenyl]-,dihydrochloride
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,7-[(2,5-difluorophenyl)methyl]-N-[4-(1,2,4-oxadiazol-3-yl)phenyl]-
4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,5-(3-aminophenyl)-N-methyl-7-(1-methylethyl)-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,4-chloro-7-[(6-chloro-4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-6-(1-pyrrolidinylmethyl)-
7H-Pyrrolo[2,3-d]pyrimidin-2-amine,7-[(6-bromo-4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-4-chloro-