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1H-Indole,5-fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulfinyl]methyl]-1-piperidinyl]ethyl]- (158848-32-9)

Identification
Name:1H-Indole,5-fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulfinyl]methyl]-1-piperidinyl]ethyl]-
Synonyms:1H-Indole,5-fluoro-3-[2-[4-methoxy-4-[(phenylsulfinyl)methyl]-1-piperidinyl]ethyl]-,(R)-; GR 159897
CAS:158848-32-9
Molecular Formula: C23H27 F N2 O2 S
Molecular Weight: 414.54
InChI: InChI=1/C23H27FN2O2S/c1-28-23(17-29(27)20-5-3-2-4-6-20)10-13-26(14-11-23)12-9-18-16-25-22-8-7-19(24)15-21(18)22/h2-8,15-16,25H,9-14,17H2,1H3/t29-/m1/s1
Molecular Structure: (C23H27FN2O2S) 1H-Indole,5-fluoro-3-[2-[4-methoxy-4-[(phenylsulfinyl)methyl]-1-piperidinyl]ethyl]-,(R)-; GR 159897
Properties
Flash Point: 316.8°C
Boiling Point: 600.2°Cat760mmHg
Density:1.29g/cm3
Refractive index:1.656
Biological Activity: A potent, selective, non-peptide, orally active neurokinin NK 2 receptor antagonist. Competes for binding of [ 3 H]GR100679 to hNK 2 -transfected CHO cells with a pK i of 9.5. Inhibits NK 2 receptor-mediated contraction of guinea pig trachea with a pA 2 of 8.7. Anxiolytic in vivo .
Flash Point: 316.8°C
Storage Temperature: −20°C
Color: off-white
Safety Data
 

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