Identification |
Name: | 2H-3,1-Benzoxazin-2-one,1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro- |
Synonyms: | Piperidine,1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)-(9CI); L 371257 |
CAS: | 162042-44-6 |
Molecular Formula: | C28H33 N3 O6 |
Molecular Weight: | 0 |
Molecular Structure: |
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Properties |
Biological Activity: | Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active. |
Safety Data |
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