| Identification | |
| Name: | 1-Propanamine,3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl- |
| Synonyms: | Dibenz[b,e]oxepin-D11(6H),g-propylamine, N,N-dimethyl-(7CI,8CI); Dibenz[b,e]oxepin, 1-propanamine deriv.;11-[3-(Dimethylamino)propylidene]-6H-dibenz[b,e]oxepin; Doxepin; Doxepine;N,N-Dimethyldibenz[b,e]oxepin-D11(6H),g-propylamine;NSC 108160 |
| CAS: | 1668-19-5 |
| Molecular Formula: | C19H21 N O |
| Molecular Weight: | 279.41 |
| InChI: | InChI=1/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/p+1/b17-11- |
| Molecular Structure: | ![(C19H21NO) Dibenz[b,e]oxepin-D11(6H),g-propylamine, N,N-dimethyl-(7CI,8CI); Dibenz[b,e]oxepin, 1-propanamine de...](https://img1.guidechem.com/chem/e/dict/24/1668-19-5.jpg) |
| Properties | |
| Density: | 1.122 g/cm3 |
| Water Solubility: | readily soluble in water, lower |
| Solubility: | readily soluble in water, lower |
| Appearance: | white crystalline solid |
| Specification: |
Doxepin is a psychotropic agent with tricyclic antidepressant and anxiolytic properties, known under many brand-names such as Aponal, the original preparation by Boehringer-Mannheim, now part of the Roche group; Adapine, Deptran, Sinquan and Sinequan (Pfizer). |
| Biological Activity: | Highly potent H 1 histamine receptor antagonist (K d = 310 pM) and tricyclic antidepressant. Also binds to the H 4 histamine receptor (pK i = 6.79). |
| Storage Temperature: | Store at RT |
| Color: | OILY LIQUID CONSISTING OF A MIXTURE OF CIS- & TRANS- ISOMERS |
| Usage: |
Doxepin (CAS NO.1668-19-5) is antidepressant used clinically to treat anxiety and depression.As doxepin hydrochloride, it is the active ingredient in cream-based preparations (Zonalon and Xepin) for the treatment of dermatological itch. Doxepin is currently investigated for the treatment of insomnia. |
| Safety Data | |
 |
|
