| Identification |
| Name: | PP1 |
| Synonyms: | 4-AMINO-5-(4-METHYLPHENYL)-7-(T-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-5-(4-METHYLPHENYL)-7-(TERT-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE;1-(TERT-BUTYL)-3-(4-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;1-(TERT-BUTYL)-3-(4-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE;1-(1,1-DIMETHYLETHYL)-1-(4-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;PP1;1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine |
| CAS: | 172889-26-8 |
| Molecular Formula: | C16H19N5 |
| Molecular Weight: | 281.36 |
| InChI: | InChI=1/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) |
| Molecular Structure: |
![(C16H19N5) 4-AMINO-5-(4-METHYLPHENYL)-7-(T-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-5-(4-METHYLPHENYL)-7-(TERT-B...](https://img.guidechem.com/structure/172889-26-8.gif) |
| Properties |
| Flash Point: | 243.4°C |
| Boiling Point: | 478.8°C at 760 mmHg |
| Density: | 1.23g/cm3 |
| Refractive index: | 1.652 |
| Appearance: | Off-white to grey solid |
| Biological Activity: | Potent inhibitor of Src-family tyrosine kinases. Inhibits p56 lck and p59 fynT (IC 50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl. |
| Flash Point: | 243.4°C |
| Usage: | A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase |
| Safety Data |
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