Methanone,(2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]- (180002-83-9)

Identification
Name:	Methanone,(2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-
Synonyms:	1H-Indole,1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]- (9CI);GW 405833;L 768242;
CAS:	180002-83-9
Molecular Formula:	C₂₃H₂₄Cl₂N₂O₃
Molecular Weight:	447.35
InChI:	InChI=1/C23H24Cl2N2O3/c1-15-17(8-9-26-10-12-30-13-11-26)19-14-16(29-2)6-7-21(19)27(15)23(28)18-4-3-5-20(24)22(18)25/h3-7,14H,8-13H2,1-2H3
Molecular Structure:
Properties
Transport:	UN 2811 6.1/PG 3
Flash Point:	283.2°C
Boiling Point:	544.6°Cat760mmHg
Density:	1.32g/cm³
Refractive index:	1.622
Biological Activity:	Potent and selective CB 2 receptor partial agonist (EC 50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB 2 receptors and displays ~ 1200-fold selectivity over CB 1 (K i values are 3.92 and 4772 nM for human recombinant CB 2 and CB 1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.
Flash Point:	283.2°C
Storage Temperature:	2-8°C
Safety Data
Hazard Symbols	T: Toxic