Biological Activity: | Potent and selective 5-HT 1D receptor agonist that displays > 600-fold selectivity over 5-HT 1A and 5-HT 2A receptors and no activity at 5-HT 1B , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 6 and 5-HT 7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation. |