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1H-Pyrazole,5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)- (188817-13-2)

Identification
Name:1H-Pyrazole,5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-
Synonyms:SC 560;5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole;5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole;
CAS:188817-13-2
Molecular Formula: C17H12ClF3N2O
Molecular Weight: 352.74
InChI: InChI=1/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
Molecular Structure: (C17H12ClF3N2O) SC 560;5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole;5-(4-Chlorophenyl)-1-(...
Properties
Flash Point: 220.3°C
Boiling Point: 440.6°Cat760mmHg
Density:1.33g/cm3
Refractive index:1.563
Biological Activity: Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.009 and 6.3 μ M for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B 2 , gastric PGE 2 and dermal PDE 2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo . Orally active.
Flash Point: 220.3°C
Storage Temperature: 2-8°C
Safety Data
Hazard Symbols Xi: Irritant
 

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