L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl- (189388-22-5)

Identification
Name:	L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-
Synonyms:	11: PN:WO2008052043 SEQID: 10 claimed protein; 1: PN: WO2009033740 PAGE: 106 claimedprotein; 39: PN: WO2005016244 PAGE: 68 claimed protein; 4: PN: EP1782819 SEQID:1 claimed protein; Endomorphin 1
CAS:	189388-22-5
Molecular Formula:	C34H38 N6 O5
Molecular Weight:	610.70
InChI:	InChI=1/C34H38N6O5/c35-26(17-22-12-14-24(41)15-13-22)34(45)40-16-6-11-30(40)33(44)39-29(19-23-20-37-27-10-5-4-9-25(23)27)32(43)38-28(31(36)42)18-21-7-2-1-3-8-21/h1-5,7-10,12-15,20,26,28-30,37,41H,6,11,16-19,35H2,(H2,36,42)(H,38,43)(H,39,44)/t26-,28-,29-,30-/m0/s1
Molecular Structure:
Properties
Density:	1.343 g/cm³
Refractive index:	1.671
Water Solubility:	soluble in water
Solubility:	soluble in water
Appearance:	Solid. (Solid powder.)
Specification:	Endomorphin-1 (EM-1) should be stored at -20°C. Keep container tightly closed.Endomorphin-1 (189388-22-5) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 (189388-22-5) activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) . However, Endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor. Endomorphin-1 (Tyr-Pro-Trp-Phe-NH₂) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH₂) are tetrapeptides with the highest known affinity and specificity for the μ opioid receptor.Endomorphin-1 is located in the nucleus of the solitary tract, the periventricular hypothalamus, and the dorsomedial hypothalamus, where it is found within histaminergic neurons and may regulate sedative and arousal behaviors.
Storage Temperature:	−20°C
Safety Data

L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl- (189388-22-5)

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