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1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]- (19794-93-5)

Identification
Name:1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-
Synonyms:s-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(m-chlorophenyl)-1-piperazinyl]propyl]- (8CI);Trazodon;2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one;
CAS:19794-93-5
EINECS: 243-317-1
Molecular Formula: C19H22ClN5O
Molecular Weight: 371.86
InChI: InChI=1/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
Molecular Structure: (C19H22ClN5O) s-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(m-chlorophenyl)-1-piperazinyl]propyl]- (8CI);Trazodon;2-...
Properties
Transport:3249
Melting Point: 86-870C
Flash Point: 273.4°C
Boiling Point: 528.5°Cat760mmHg
Density:1.33g/cm3
Refractive index:1.67
Water Solubility:Freely soluble p
Solubility:Freely soluble p
Appearance:White to off-white crystalline powder
Specification:

1.Warnings
(1).If the patient has a known hypersensitivity to trazodone.
(2If the patient is under 18 years of age and combines with other antidepressant medications it may greatly increase the possibility of suicidal thoughts or actions.
2.Side Effects
The most common adverse reactions encountered are drowsiness, nausea/vomiting, headache and dry mouth. Adverse reactions reported include the following:[citation needed]
3.Drug Interactions
(1).Trazodone (19794-93-5) may enhance the effects of alcohol, barbiturates and other CNS depressants; patients should be cautioned accordingly as trazodone with the combination of another CNS depressant, can result in extreme tiredness and dizziness.
(2).Increased serum digoxin and phenytoin levels have been reported to occur in patients receiving trazodone concurrently with either of those 2 drugs. Little is known about the interaction between trazodone and general anesthetics; therefore, prior to elective surgery, trazodone should be discontinued for as long as clinically feasible.

Packinggroup: III
Flash Point: 273.4°C
Usage:Antidepressant
Safety Data
Hazard Symbols
 

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