| Identification |
| Name: | Benzo[b]thiophene,6-nitro-, 1,1-dioxide |
| Synonyms: | 6-Nitrobenzo[b]thiophene1,1-dioxide; Stattic |
| CAS: | 19983-44-9 |
| Molecular Formula: | C8H5 N O4 S |
| Molecular Weight: | 211.19 |
| InChI: | InChI=1/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H |
| Molecular Structure: |
![(C8H5NO4S) 6-Nitrobenzo[b]thiophene1,1-dioxide; Stattic](https://img1.guidechem.com/chem/e/dict/23/19983-44-9.jpg) |
| Properties |
| Flash Point: | 232.6°C |
| Boiling Point: | 461.1°Cat760mmHg |
| Density: | 1.621g/cm3 |
| Refractive index: | 1.671 |
| Biological Activity: | Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. |
| Flash Point: | 232.6°C |
| Safety Data |
| Hazard Symbols |
Xi: Irritant
Xn: Harmful
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