| Identification |
| Name: | 1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl- |
| Synonyms: | AM 281;1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide; |
| CAS: | 202463-68-1 |
| Molecular Formula: | C21H19Cl2IN4O2 |
| Molecular Weight: | 557.21 |
| InChI: | InChI=1/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29) |
| Molecular Structure: |
 |
| Properties |
| Transport: | UN 2811 6 |
| Flash Point: | °C |
| Boiling Point: | °Cat760mmHg |
| Density: | 1.7g/cm3 |
| Refractive index: | 1.706 |
| Water Solubility: | Soluble in methanol (1mg/ml) or DMSO (2mg/ml at RT, 50mg/ml in hot DMSO |
| Solubility: | Soluble in methanol (1mg/ml) or DMSO (2mg/ml at RT, 50mg/ml in hot DMSO |
| Appearance: | White to off-white solid. |
| Biological Activity: | Potent, selective CB 1 cannabinoid receptor antagonist/inverse agonist (K i values are 12 and 4200 nM for CB 1 and CB 2 receptors respectively). Increases locomotor activity following systemic administration in vivo . Analog of SR141716A (K i = 14 nM). |
| Flash Point: | °C |
| Storage Temperature: | 2-8°C |
| Color: | white |
| Safety Data |
| Hazard Symbols |
T: Toxic
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