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2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro- (2062-78-4)

Identification
Name:2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-
Synonyms:2-Benzimidazolinone,1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]- (7CI,8CI);1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperindinyl)-1,3-dihydro-2H-benzimidazol-2-one;1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone;1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; NSC170984; Orap; Pimozide; Primozide; R 6238
CAS:2062-78-4
EINECS: 218-171-7
Molecular Formula: C28H29 F2 N3 O
Molecular Weight: 461.60
InChI: InChI=1/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
Molecular Structure: (C28H29F2N3O) 2-Benzimidazolinone,1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]- (7CI,8CI);1-(1-(4,4-Bis(4-fluo...
Properties
Transport:3249
Flash Point: °C
Boiling Point: °Cat760mmHg
Density:1.224g/cm3
Refractive index:1.596
Specification:

Contraindications and precautions:
1.Contraindicated in patients taking citalopram (Celexa) and escitalopram (Lexapro) due to prolongation of the QTc interval, as per the FDA.
2.Patients with prominent agitation or anxiety
3.Depressed patients
4.Severe intoxication with alcohol, opiates, and psychoactive drugs (e.g. antidepressants, benzodiazepines)
5.Preexisting Parkinson's disease
6.Comedication with nefazodone, clarithromycin and vetoconazol (see below under interactions)
7.Caution: Anticonvulsive treatment in epileptic patients should not be interrupted. Pimozide may in principle lower the seizure-threshold.
8.Caution: Patients under 18 yrs. of age. Side-effects may be particularly frequent and severe. Treatment should be started with low initial dose and the dose increased very slowly.

Packinggroup: III
Biological Activity: Dopamine D 2 -receptor antagonist and antipsychotic which binds with very high affinity to the cloned rat 5-HT 7 receptor (K i = 0.5 nM).
Flash Point: °C
Storage Temperature: 2-8°C
Safety Data
Hazard Symbols Xn: Harmful
 

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