| Identification | |
| Name: | DAPT |
| CAS: | 208255-80-5 |
| Molecular Formula: | C23H26F2N2O4 |
| Molecular Weight: | 432.464 |
| InChI: | InChI=1/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1 |
| Molecular Structure: | ![(C23H26F2N2O4) LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;γ-Secretase Inhibi...](https://img.guidechem.com/structure/208255-80-5.gif) |
| Properties | |
| Flash Point: | 324.1°C |
| Boiling Point: | 612.2°C at 760 mmHg |
| Density: | 1.213g/cm3 |
| Refractive index: | 1.534 |
| Solubility: | 18 mg/mL in DMSO |
| Appearance: | white solid |
| Biological Activity: | Inhibitor of γ -secretase; causes a reduction in A β 40 and A β 42 levels in human primary neuronal cultures (IC 50 values are 115 and 200 nM for total A β and A β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . Does not effect APP α and APP β levels. Blocks Notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. |
| Flash Point: | 324.1°C |
| Storage Temperature: | 2-8°C |
| Color: | white |
| Safety Data | |
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