Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy- (2086-83-1)

 Berberine ,its cas register number is 2086-83-1. It also can be called Umbellatine ; Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)- ; 7,8,13,13a-Tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium and 5,6-Dihydro-9,10-dimethoxybenzo[g]1,3-benzodioxolo[5,6-a]quinolizinium . It is a quaternary ammonium salt from the group of isoquinoline alkaloids. It is found in such plants as Berberis, goldenseal (Hydrastis canadensis), and Coptis chinensis, usually in the roots, rhizomes, stems, and bark.
 Berberine (CAS NO.2086-83-1) (BBR) is a natural compound with up-regulating activity on both low-density-lipoprotein receptor (LDLR) and insulin receptor (InsR).Berberine has been tested and used successfully in experimental and human diabetes mellitus. It lowers elevated blood total cholesterol, LDL cholesterol, triglycerides and aterogenic apolipoproteins (apo B) (Apo B), but the mechanism of action is distinct from statins. It seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders, and  inhibits prolyl oligopeptidase (POP) in a dose-dependent manner. Berberine inhibits prolyl oligopeptidase (POP) in a dose-dependent manner. And it has drawn extensive attention towards its antineoplastic effects.