Phenanthro[3,2-b]furan-7,11-dione,8,9-dihydro-4,8-dimethyl- (20958-18-3)

The IUPAC name of Dihydrotanshinone is 4,8-dimethyl-8,9-dihydronaphtho[2,1-f][1]benzofuran-7,11-dione . With the CAS registry number 20958-18-3, it is also named as Phenanthro(3,2-b)furan-7,11-dione, 8,9-dihydro-4,8-dimethyl- ; 4,8-Dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione ; Phenanthro[3,2-b]furan-7,11-dione, 8,9-dihydro-4,8-dimethyl- ; Dihydroisotanshinone I .

The Dihydrotanshinone is red crystal. It is soluble in chloroform, acetone and other organic solvents, slightly soluble in water. Dihydrotanshinone must store in cool and dry place. And it must avoid light and high temperature. It has antibacterial, antifungal activity against Staphylococcus aureus, human-type Mycobacterium tuberculosis, Mycobacterium, leather bacteria etc to some extent. It also has inhibition of platelet aggregation, anti-oxidants, such as active coronary expansion.

Some scientists found that dihydrotanshinone exhibited cytotoxicity against various tumor cell lines. To investigate whether the mechanism underlying dihydrotanshinone toxicity involved apoptosis in cancer cell lines, they examined cell growth arrest and cell death by flow cytometric analysis and DNA fragmentation assay. Dihydrotanshinone induced cell growth arrest during the S phase and subsequently, apoptosis, following its application to K562/ADR cells, whereas cryptotanshinone did not have these effects. These results suggest that the mode of action of dihydrotanshinone involves apoptotic pathways that are different from those involved in cryptotanshinone toxicity.

The other characteristics of this product can be summarized as: (1) H bond acceptors: 3; (2) H bond donors: 0; (3) Index of Refraction: 1.67; (4) Molar Refractivity: 78.65 cm³; (5) Molar Volume: 210.3 cm³; (6) Polarizability: 31.18×10^-24 cm³; (7) Surface Tension: 55.9 dyne/cm; (8) Enthalpy of Vaporization: 73.29 kJ/mol; (9) Vapour Pressure: 5.1E-09 mmHg at 25°C.People can use the following data to convert to the molecule structure. SMILES: O=C2C=1OCC(C=1C(=O)c4c2c3cccc(c3cc4)C)C; InChI: InChI=1/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)18-14(16(13)19)10(2)8-21-18/h3-7,10H,8H2,1-2H3.