| Identification | |
| Name: | Methyllycaconitine |
| Synonyms: | 14,16-tetramethoxy-,(1-alpha,4(s),6-beta,14-alpha,16-beta)-oxy)methyl)-6;aconitane-7,8-diol,20-ethyl-4-(((2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl);delartine;delsemidine;methyl-lycaconitin;METHYLLYCACONITINE CITRATE MLA:SYNTHETIC;METHYLLYCACONITINE CITRATE HYDRATE FROM DELPHINIUM BROWNII SEEDS;(1a,4(S),6b,14a,16b)-20-Ethyl-1,6,14,16-tetramethoxy-4-(((2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl)oxy)methyl)aconi |
| CAS: | 21019-30-7 |
| Molecular Formula: | C37H50N2O10 |
| Molecular Weight: | 874.92 |
| InChI: | InChI=1/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19?,21?,22-,24+,25?,27-,28?,29-,30+,33+,34+,35-,36?,37+/m1/s1 |
| Molecular Structure: |  |
| Properties | |
| Flash Point: | 440.5°C |
| Boiling Point: | 804.8°C at 760 mmHg |
| Density: | 1.37g/cm3 |
| Refractive index: | 1.626 |
| Specification: |
Methyllycaconitine (CAS NO.21019-30-7) is also called 4-21-00-04589 (Beilstein Handbook Reference) ; BRN 0076234 ; Delartine ; Delsemidine ; Lycaconitine, methyl- ; Aconitane-7,8-diol, 20-ethyl-1,6,14,16-tetramethoxy-4-(((2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl)oxy)methyl)-, (1alpha,4(S),6beta,14alpha,16beta)- ; Aconitane-7,8-diol, 20-ethyl-4-(((2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl)oxy)methyl)-1,6,14,16-tetramethoxy-, (1-alpha,4(S),6-beta,14-alpha,16-beta)- . Methyllycaconitine (CAS NO.21019-30-7) is white solid. Methyllycaconitine (CAS NO.21019-30-7) is high toxic. It is flammable by fire, heat and oxidants. It will produce toxic nitrogen oxide fumes when buring. So the storage environment should be ventilate, low-temperature and dry. Keep Methyllycaconitine (CAS NO.21019-30-7) separate from raw materials of food. Methyllycaconitine (MLA) is a plant alkaloid found in the larkspur, and has been identified as an antagonist of nicotinic acetylcholine receptors (nAChrs) in the muscle and brain. It is one of many alkaloids found in the larkspur, but is believed to be one of the major culprits in the poisoning of livestock in the Western United States. |
| Biological Activity: | Potent antagonist for α 7-containing neuronal nicotinic receptors (K i = 1.4 nM). Interacts with α 4 β 2 and α 6 β 2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo . |
| Flash Point: | 440.5°C |
| Storage Temperature: | −20°C |
| Color: | white |
| Safety Data | |
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