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(S)-5-Iodo-3-[(2-azetidinyl)-methoxy]pyridine (213764-92-2)

Identification
Name:(S)-5-Iodo-3-[(2-azetidinyl)-methoxy]pyridine
Synonyms:Pyridine, 3-[(2S)-2-azetidinylmethoxy]-5-iodo-, hydrochloride (1:2);
CAS:213764-92-2
Molecular Formula: C9H13Cl2IN2O
Molecular Weight: 363.03
InChI: InChI=1/C9H11IN2O.2ClH/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8;;/h3-5,8,12H,1-2,6H2;2*1H/t8-;;/m0../s1
Molecular Structure: (C9H13Cl2IN2O) Pyridine, 3-[(2S)-2-azetidinylmethoxy]-5-iodo-, hydrochloride (1:2);
Properties
Flash Point: 210.9°C
Boiling Point: 425.2°C at 760 mmHg
Water Solubility:Soluble to 100 mM in Water and to 100 mM in DMSO
Biological Activity: A highly potent and subtype-selective agonist for the α 4 β 2 and α 6 β 2 nicotinic acetylcholine receptors. Activates α -CTx-MII-sensitive and -insensitive components of [ 3 H]dopamine release from rat striatal synaptosomes, corresponding to α 6 β 2 and α 4 β 2 (EC 50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α 3 β 4, α 7 and muscle nAChR receptors respectively.
Flash Point: 210.9°C
Safety Data