Identification |
Name: | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(1,3-dioxo-3-phenoxy-2-phenylpropyl)amino]-3,3-dimethyl-7-oxo-, sodiumsalt (1:1), (2S,5R,6R)- |
Synonyms: | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(1,3-dioxo-3-phenoxy-2-phenylpropyl)amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(1,3-dioxo-3-phenoxy-2-phenylpropyl)amino]-3,3-dimethyl-7-oxo-, monosodiumsalt, [2S-(2a,5a,6b)]-; Malonamic acid,N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenyl-,1-phenyl ester, monosodium salt (8CI); BRL 3475; Carbenicillin phenyl sodium;Carfecillin sodium; Carfecillin sodium salt; Gripenin O; Sodium carfecillin;Urocarf; Uticillin |
CAS: | 21649-57-0 |
EINECS: | 244-496-9 |
Molecular Formula: | C23H22 N2 O6 S . Na |
Molecular Weight: | 476.51 |
InChI: | InChI=1/C23H22N2O6S.Na/c1-23(2)17(21(28)29)25-19(27)16(20(25)32-23)24-18(26)15(13-9-5-3-6-10-13)22(30)31-14-11-7-4-8-12-14;/h3-12,15-17,20H,1-2H3,(H,24,26)(H,28,29);/q;+1/p-1/t15?,16-,17+,20-;/m1./s1 |
Molecular Structure: |
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Properties |
Flash Point: | 420°C |
Boiling Point: | 770.9°Cat760mmHg |
Density: | g/cm3 |
Specification: |
Its extinguishing agent are water, carbon dioxide, dry powder, foam. Carbenicillin phenyl sodium (CAS NO.21649-57-0) in aqueous solution at 35 degrees and at 0.5 ionic strength were investigated. The reactions were followed by spectrophotometric assay , reversed-phase high-pressure liquid chromatography, and colorimetric assay . The degradation pathways were established, and the rate-pH profiles for ester and beta-lactam cleavage reactions are given for pH 1-11. Below pH 3, the beta-lactam degradation of the prodrugs proceeded exclusively. Above pH 7, the degradation was superseded by the ester hydrolysis to carbenicillin , beta-Lactams of both prodrugs are around three times more stable than carbenicillin disodium at pH 1, six times at PH 2, and 17 times at pH 3. The half-lives for carbenicillin production were predicted to be 17 hr for Carbenicillin phenyl sodium (CAS NO.21649-57-0) and 8.5 hr for carbenicillin phenyl sodium at pH 7.0 and 37 degrees.
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Flash Point: | 420°C |
Safety Data |
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